Development of Thiadiazole and Schiff Base Derivatives: Synthesis, Spectral Characterization, and Antibacterial Activity Assessment
Abstract
Given the significant importance and distinctive applications of Schiff base compounds in both academic and applied fields, this study focused on the synthesis of a new heterocyclic compound. Several spectroscopic techniques were employed to characterize the synthesized compound after precipitation and purification. These techniques included: Proton nuclear magnetic resonance spectroscopy (¹H-NMR) and Fourier-transform infrared spectroscopy (FT-IR). The solubility of the compound was also evaluated. It was found to be highly soluble in ethanol, methanol, dimethyl sulfoxide (DMSO), and tetrahydrofuran (THF), whereas it was insoluble in water and diethyl ether , In addition, the biological activity of the synthesized compound was investigated against selected strains of Gram-positive and Gram-negative bacteria. The compound exhibited moderate to high antibacterial activity, which suggests its potential as a candidate for further pharmacological development.
Downloads
Copyright (c) 2025 (Humanities, social and applied sciences) Misan Journal of Academic Studies

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The copyright is also the copyright of the magazine only.
All articles published in our magazine are subject to license terms
Creative Commons Attribution(CC BY-NC-ND 4.0) This license permits the content to be reproduced, redistributed and reused in whole or in part for any purpose free of charge, without any permission from the author(s), researcher or student.
Works submitted to Maysan Journal of Academic Studies for publication in the journal (CC BY-NC-ND 4.0) license terms. Where available content can be shared, distributed and replicated provided there is no commercial profit and appropriate credit must be given to the original source through sources or citations. It is mandatory to review any material used from other sources including shapes, tables, and images for re-use under the terms of the Creative Commons License (CC BY-NC-ND 4.0).Provided that there is no modification to the original content