Development of Thiadiazole and Schiff Base Derivatives: Synthesis, Spectral Characterization, and Antibacterial Activity Assessment
Abstract
Given the significant importance and distinctive applications of Schiff base compounds in both academic and applied fields, this study focused on the synthesis of a new heterocyclic compound. Several spectroscopic techniques were employed to characterize the synthesized compound after precipitation and purification. These techniques included: Proton nuclear magnetic resonance spectroscopy (¹H-NMR) and Fourier-transform infrared spectroscopy (FT-IR). The solubility of the compound was also evaluated. It was found to be highly soluble in ethanol, methanol, dimethyl sulfoxide (DMSO), and tetrahydrofuran (THF), whereas it was insoluble in water and diethyl ether , In addition, the biological activity of the synthesized compound was investigated against selected strains of Gram-positive and Gram-negative bacteria. The compound exhibited moderate to high antibacterial activity, which suggests its potential as a candidate for further pharmacological development.
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