The Interplay Between Chronic Kidney Disease and Periodontal Health: A Comprehensive Review
Abstract
Chronic kidney disease (CKD) and periodontal disease are both
chronic conditions with systemic implications, yet their potential interplay
remains underexplored. This comprehensive review aims to elucidate the
association between CKD and periodontal health status. Several
mechanisms underlie the association between CKD and periodontal health.
Shared risk factors such as diabetes, hypertension, and inflammation
contribute to the development and progression of both conditions.
Additionally, CKD-related immune dysfunction and impaired wound
healing may exacerbate periodontal inflammation and tissue destruction,
while periodontal pathogens and their byproducts may exacerbate systemic
inflammation and renal injury in CKD patients.
Understanding the complex interplay between CKD and periodontal
health status is crucial for comprehensive patient management.
Multidisciplinary approaches integrating nephrology and periodontology
are warranted to optimize the oral and systemic health outcomes of CKD
patients. Future research should focus on elucidating the mechanistic
pathways linking CKD and periodontal disease and evaluating the efficacy
of periodontal interventions in improving renal outcomes in CKD
populations.
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