Evaluation the Salivary levels of Interleukin-23 in Individuals with Thyroid Disorders

الملخص

   Background: The study investigates the role of IL-23 in autoimmune thyroid disorders, focusing on patients with hypothyroidism and hyperthyroidism.

  Material and Methods: This case-control research was conducted at Baghdad Teaching Hospital from January to May 2023. Saliva samples were collected from 87 participants, including 29 with hypothyroidism, 29 with hyperthyroidism, and 29 healthy controls. Saliva samples were analyzed for IL-23 levels using ELISA assays, while thyroid function tests (FT3, FT4, TSH) were conducted using the cobas c 111 colorimetric method.

   Results: The study found a significant difference in IL-23 levels between the hyperthyroid group and the control group (P<0.01). However, no significant difference in IL-23 levels was observed in the hypothyroid group compared to controls (P>0.05). The age distribution showed no significant differences across patient groups (P>0.05), while gender distribution indicated a higher prevalence of thyroid disorders in females.

Conclusion: IL-23 serves as a significant marker for hyperthyroidism diagnosis, but further research is needed to explore its role in hypothyroidism. The study supports IL-23's involvement in autoimmune responses and its potential as a diagnostic tool for thyroid disorders.