The Relationship Between Periodontitis Severity and MCP-1, IL-6 Levels in Gingival Crevicular Fluid
Abstract
Periodontitis is an inflammatory disorder that affects the teeth's supporting structures, leading to attachment loss and bone resorption. Cytokines produced by immune and non-immune cells regulate the immune response, acting as both pro-inflammatory and anti-inflammatory agents. This complex pathogenesis presents a significant public health challenge, emphasizing the need for early and accurate diagnostics. This study aimed to measure volume of gingival crevicular fluid (GCF) using Periotron® and assess potential biomarkers (MCP-1 and IL-6) to predict periodontal disease severity and progression using the Human Enzyme-linked immunosorbent Assay (ELISA). GCF samples were collected from 30 patients with stage 1 periodontitis, 30 patients with stage 3 periodontitis, and 30 healthy subjects. The level of GCF recorded using Periotron® was 0.04 µl for the healthy control group, 0.10 µl for the stage 1 periodontitis group, and 0.70 µl for the stage 3 periodontitis group. MCP-1 and IL-6 levels in the GCF were significantly higher in the stage 3 periodontitis group compared to the stage 1 periodontitis group and healthy subjects.
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